Linked Life Data

3311004

Source:http://linkedlifedata.com/resource/pubmed/id/3311004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-11-17
pubmed:abstractText
Raised plasma non-esterified fatty acids (NEFA) have been directly implicated in the development of serious ventricular arrhythmias and death during acute myocardial infarction. Since this was first proposed by Oliver and Kurien in 1970, clinical and experimental evidence has been conflicting, but results of clinical studies with antilipolytic drugs suggested a reduction in ventricular tachycardia. Lowering of raised NEFA by antilipolytic therapy in dogs was effective, whilst raising NEFA, either by intravascular lipolysis or direct infusion, failed to precipitate VF. An alternative hypothesis is proposed, which suggests that a fatty acid--triglyceride energy wasting cycle operates at different rates within the ischaemic heart, and caused differential rates of K+ loss, leading to ventricular fibrillation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8428
pubmed:author
pubmed:issnType
Print
pubmed:volume
82 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-86
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Raised plasma non-esterified fatty acids (NEFA) during ischaemia: implications for arrhythmias.
pubmed:affiliation
Cardiovascular Research Unit, University of Edinburgh, Scotland.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't