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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1987-11-12
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated the cDNA for human lymphocyte function-associated antigen 3 (LFA-3), the ligand of the T lymphocyte CD2 molecule. The identity of the clones was established by comparison of the deduced amino acid sequence to the LFA-3 NH2-terminal and tryptic peptide sequences. The cDNA defines a mature protein of 222 amino acids that structurally resembles typical membrane-anchored proteins. An extracellular domain with six N-linked glycosylation sites is followed by a hydrophobic putative transmembrane region and a short cytoplasmic domain. The mature glycoprotein is estimated to be 44-68% carbohydrate. Southern blots of human genomic DNA indicate that only one gene codes for human LFA-3. Northern blot analysis demonstrates that the LFA-3 mRNA of 1.3 kb is widely distributed in human tissues and cell lines.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2418980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2437578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2883656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2933745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2951597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2959270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-2983426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3081518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3093887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3098838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3102667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3102675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3102676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3102975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3309123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3490670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3548764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3754790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-3893568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6189829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6198242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6201533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6287227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6327874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6345670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-6855576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-72068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-7263636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3309127-7276066
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
923-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3309127-Amino Acid Sequence,
pubmed-meshheading:3309127-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3309127-Antigens, Surface,
pubmed-meshheading:3309127-Base Sequence,
pubmed-meshheading:3309127-Cloning, Molecular,
pubmed-meshheading:3309127-DNA,
pubmed-meshheading:3309127-Humans,
pubmed-meshheading:3309127-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:3309127-Molecular Sequence Data,
pubmed-meshheading:3309127-Peptide Mapping
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pubmed:year |
1987
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pubmed:articleTitle |
Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.
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pubmed:affiliation |
Biogen Research Corporation, Cambridge, Massachusetts 02142.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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