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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1987-10-21
|
| pubmed:abstractText |
From 1966 through 1985, a total of 640 patients received 739 renal transplants at a single center transplantation program. Of 245 total deaths, a slide and chart review of all 116 autopsied cases (47%) identified the major causes of death as pneumonia (n = 43), sepsis (n = 32), hemorrhage (n = 15), peritonitis (n = 11), meningitis (n = 7), and pulmonary embolism (n = 5). Eighty-five (73.3%) of these patients died of complications directly associated with immunosuppression, almost all (n = 82) as a result of infection. Organisms most frequently identified at death were gram-negative bacilli (n = 72), Candida species (n = 23), cytomegalovirus (n = 17), enterococcus (n = 14), Staphylococcus aureus (n = 11), Aspergillus species (n = 10), Pneumocystis carinii (n = 5), and mycobacteria (n = 5). Significant associations were found between bolus steroid antirejection therapy and infection with Aspergillus cytomegalovirus. Diabetics had a higher incidence of fungal infections and bowel perforation than nondiabetics. During this 20-year period, overall one-year actual patient survival rates for the four respective five-year intervals increased dramatically (69.9%, 68.2%, 83.3%, and 91.8%), but the normalized death rate showed a smaller decrease for infectious vs noninfectious causes.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0003-9985
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
983-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3307685-Adolescent,
pubmed-meshheading:3307685-Adult,
pubmed-meshheading:3307685-Bacterial Infections,
pubmed-meshheading:3307685-Child,
pubmed-meshheading:3307685-Diabetes Complications,
pubmed-meshheading:3307685-Female,
pubmed-meshheading:3307685-Humans,
pubmed-meshheading:3307685-Immunosuppression,
pubmed-meshheading:3307685-Kidney Failure, Chronic,
pubmed-meshheading:3307685-Kidney Transplantation,
pubmed-meshheading:3307685-Male,
pubmed-meshheading:3307685-Middle Aged,
pubmed-meshheading:3307685-Mycoses,
pubmed-meshheading:3307685-Postoperative Complications
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Causes of death in renal transplant recipients. A review of autopsy findings from 1966 through 1985.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|