Linked Life Data

3305942

Source:http://linkedlifedata.com/resource/pubmed/id/3305942

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-10-5
pubmed:abstractText
Human articular cartilage cultured in the presence of interleukin 1 (IL-1) produced from activated peripheral blood mononuclear cells, exhibits the concomitant release of a latent metalloproteinase and fragments of proteoglycan. The manner in which the activated form of the metalloproteinase degrades proteoglycan subunit and link protein suggests a role for this enzyme in cartilage degradation in vivo. While cartilage cultured in the continuous presence of purified IL-1 shows sustained release of metalloproteinase, tissue cultured in the presence of the total products released by activated mononuclear cells from some individuals showed initial stimulation followed by a decline, suggesting the presence of a modulator of IL-1 action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0315-162X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14 Spec No
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
86-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The role of mononuclear cell products as modulators of cartilage degradation.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't