Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1987-7-10
|
pubmed:abstractText |
The effect of a single intragastric injection of 1,2-dibromoethane was investigated in kidneys of male Wistar rats. DNA synthesis as measured by the incorporation of tritiated thymidine was found to be approximately 5 times greater than that of controls 20-30 h after treatment. DNA synthesis was followed by a striking increase in the mitotic activity with a maximum at 30 h. The labeling and mitotic activities, after an initial increase, fell rapidly 48 h after treatment even though they were still higher than those of control animals. 1,2-Dibromoethane-induced cell proliferation is not a regenerative response because at the dose used in this study, no tubular necrosis was observed by histologic examination.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0378-4274
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
37
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
85-90
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3296322-Animals,
pubmed-meshheading:3296322-Cell Division,
pubmed-meshheading:3296322-DNA,
pubmed-meshheading:3296322-Ethylene Dibromide,
pubmed-meshheading:3296322-Hydrocarbons, Brominated,
pubmed-meshheading:3296322-Kidney,
pubmed-meshheading:3296322-Male,
pubmed-meshheading:3296322-Mitosis,
pubmed-meshheading:3296322-Rats,
pubmed-meshheading:3296322-Rats, Inbred Strains,
pubmed-meshheading:3296322-Thymidine
|
pubmed:year |
1987
|
pubmed:articleTitle |
Cell proliferation in rat kidney induced by 1,2-dibromoethane.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|