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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-8-17
|
| pubmed:abstractText |
Spleen cells from BALB/c mice, infected 14 to 28 days earlier with Friend leukemia virus (FLV), were shown to be inhibited in their ability to produce interleukin 2 (IL-2) when stimulated with mitogen. Likewise, these spleen cell populations failed to respond following mitogenic stimulation or exogenous addition of recombinant IL-2. By contrast, the FLV-infected spleen cell populations produced normal levels of interleukin 1 (IL-1) and thymocytes from FLV-infected mice responded normally to addition of exogenous IL-1. This suggests that FLV infection selectively affects the ability of spleen cells to produce cytokines. Spleen cell populations enriched for T lymphocytes and depleted of tumor cells by density gradient centrifugation in Ficoll were unable to produce IL-2. This indicates that the failure to detect IL-2 in cells from FLV-infected mice was not due to a dilution of T lymphocytes by tumor cells but was a functional inability to produce IL-2. Furthermore, enriched T lymphocytes from FLV-infected mice failed to respond blastogenically to exogenous IL-2. Additional studies indicate that tumor cells, but not macrophages or T lymphocytes from FLV-infected spleens, suppressed the blastogenic response to mitogens and IL-2 production by normal splenic T lymphocytes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0037-9727
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
188
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
353-63
|
| pubmed:dateRevised |
2007-11-2
|
| pubmed:meshHeading |
pubmed-meshheading:3293056-Animals,
pubmed-meshheading:3293056-Cell Separation,
pubmed-meshheading:3293056-Cells, Cultured,
pubmed-meshheading:3293056-Centrifugation, Density Gradient,
pubmed-meshheading:3293056-Escherichia coli,
pubmed-meshheading:3293056-Female,
pubmed-meshheading:3293056-Friend murine leukemia virus,
pubmed-meshheading:3293056-Interleukin-1,
pubmed-meshheading:3293056-Interleukin-2,
pubmed-meshheading:3293056-Leukemia, Experimental,
pubmed-meshheading:3293056-Lipopolysaccharides,
pubmed-meshheading:3293056-Macrophages,
pubmed-meshheading:3293056-Mice,
pubmed-meshheading:3293056-Mice, Inbred BALB C,
pubmed-meshheading:3293056-Mice, Inbred C3H,
pubmed-meshheading:3293056-Phytohemagglutinins,
pubmed-meshheading:3293056-Recombinant Proteins,
pubmed-meshheading:3293056-Spleen,
pubmed-meshheading:3293056-T-Lymphocytes
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Altered interleukin production during Friend leukemia virus infection.
|
| pubmed:affiliation |
Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, Tampa 33612.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|