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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-8-24
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pubmed:abstractText |
To identify whether microtubules are involved in the maintenance of vacuolar morphology, we treated Saccharomyces cerevisiae with nocodazole and methyl benzimidazole-2-yl-carbamate, drugs which inhibit the polymerization of microtubules. Treated cells arrest with a single large bud in the G2/prophase portion of the cell cycle. Labeling the vacuole with either quinacrine or FITC-dextran revealed vacuole fragmentation that was not found in untreated cells or in cells arrested in G2 by unrelated means. A drug-resistant mutant in beta tubulin does not show vacuolar fragmentation when treated with drug. We propose that microtubules are involved in the regulation of vacuole morphology.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-14434278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-2411550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-2444598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-2445758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-2580633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-2581316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-27718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-2998923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-3517870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-3530761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-3540600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-3550801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-3892306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-423323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6120174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6207183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6343284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6361497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6365930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-637845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6380751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6381504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6501419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6746742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6814941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-6998984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-7014573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-7046050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-7188254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292537-7357605
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9525
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Yeast vacuoles fragment when microtubules are disrupted.
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pubmed:affiliation |
Molecular Biology Institute, University of California, Los Angeles 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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