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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-8-24
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pubmed:abstractText |
The murine response to bromelain-treated mouse red blood cells (BrMRBC) is derived from Ly-1 B cells. It has been proposed that this B-cell subset produces a variety of other autoantibodies and is elevated in autoimmune mouse strains. We have studied the ability of MRL lpr/lpr and the non-autoimmune congenic MRL +/+ mice to make autoantibodies to BrMRBC and immunoglobulin (rheumatoid factors, RF). Following lipopolysaccharide (LPS) stimulation we found the numbers of autologous plaque-forming cells (PFC) to be low in both lpr and MRL +/+ mice, suggesting low Ly-1 B-cell numbers. This observation is consistent with the view that Ly-1 B cells in the mouse may not give rise to pathologically relevant RF.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-2416866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-2947846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-3096879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-309911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-3106981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-316393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-3487115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-3894936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-3917672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-4140475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-51479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-5653817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-566858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-6157989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-6338123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-6444324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-6600267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-6609363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3292411-6972993
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3292411-Animals,
pubmed-meshheading:3292411-Antibody-Producing Cells,
pubmed-meshheading:3292411-Antigens, Ly,
pubmed-meshheading:3292411-Autoantibodies,
pubmed-meshheading:3292411-Autoimmune Diseases,
pubmed-meshheading:3292411-B-Lymphocytes,
pubmed-meshheading:3292411-Erythrocytes,
pubmed-meshheading:3292411-Hemolytic Plaque Technique,
pubmed-meshheading:3292411-Lipopolysaccharides,
pubmed-meshheading:3292411-Mice,
pubmed-meshheading:3292411-Mice, Inbred Strains,
pubmed-meshheading:3292411-Rheumatoid Factor,
pubmed-meshheading:3292411-Spleen
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pubmed:year |
1988
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pubmed:articleTitle |
The relationship between induced and spontaneous autoantibodies in MRL mice: the role of Ly-1 B cells?
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pubmed:affiliation |
Department of Immunology, Middlesex Hospital Medical School, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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