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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-8-25
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pubmed:abstractText |
The coordinate expression of the nuclear p53 protein, cytoplasmic intermediate filament vimentin (VIM) and membrane epidermal growth factor receptor (EGF-R) was significantly associated with oestrogen receptor immunocytochemical nuclear stain (ER-ICA) negative breast carcinomas. Twenty-three (51.1%), 26 (57.8%) and 27 (60%) of 45 ER-ICA -ve cancers were respectively p53 +ve, VIM +ve and EGF-R +ve; whereas of 151 ER-ICA +ve tumours 8 (5.3%) were p53 +ve (P less than 0.0001), 23 (15.2%) VIM +ve (P less than 0.001) and 40 (26.5%) EGF-R +ve P less than 0.001). Thirty-six of 45 (80%) ER-ICA -ve carcinomas were positive for at least one of the markers versus 55/151 (36.4%) ER-ICA +ve cases (chi 2 = 28.92, P less than 0.001). A prevalence of high grade carcinomas was found among p53 +ve, VIM +ve cases; the latter subset of tumours also had a larger mean diameter. These results suggest that ER -ve breast carcinoma cells display a coordinate expression of cell cycle-related proteins and marked changes of both the cytoskeleton and the membrane receptor repertoire.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-13499785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2417531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2432361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2433835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2435565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2443000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2821401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2867728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-2884496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3012540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3030941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3034415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3276632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3458185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3467175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3715461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3774012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3783323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3840362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3861896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3930272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-3986805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6092064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6095116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6186672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6189127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6292898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6302699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6320011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6692367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3291921-6729213
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Vimentin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3291921-Adult,
pubmed-meshheading:3291921-Aged,
pubmed-meshheading:3291921-Aged, 80 and over,
pubmed-meshheading:3291921-Breast Neoplasms,
pubmed-meshheading:3291921-Female,
pubmed-meshheading:3291921-Humans,
pubmed-meshheading:3291921-Male,
pubmed-meshheading:3291921-Middle Aged,
pubmed-meshheading:3291921-Neoplasm Proteins,
pubmed-meshheading:3291921-Nuclear Proteins,
pubmed-meshheading:3291921-Phosphoproteins,
pubmed-meshheading:3291921-Prognosis,
pubmed-meshheading:3291921-Receptor, Epidermal Growth Factor,
pubmed-meshheading:3291921-Receptors, Estrogen,
pubmed-meshheading:3291921-Receptors, Progesterone,
pubmed-meshheading:3291921-Tumor Suppressor Protein p53,
pubmed-meshheading:3291921-Vimentin
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pubmed:year |
1988
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pubmed:articleTitle |
Vimentin and p53 expression on epidermal growth factor receptor-positive, oestrogen receptor-negative breast carcinomas.
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pubmed:affiliation |
Division of Anatomic Pathology and Cytology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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