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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1988-8-24
|
| pubmed:abstractText |
This paper responds to the recent article by Rao et al. (Alcohol and Alcoholism 21, 369-373, 1986) which suggested that the Lieber-De Carli liquid diet for chronic ethanol-feeding studies may not be suitable for the rat because of the changes in carbohydrate content. The viability of the Lieber-De Carli model was, therefore, re-examined. The content of the liquid diet was shown to be nutritionally adequate, when compared to a solid laboratory chow. However, rats on an alcohol feeding regime had sub-optimal growth rates, because of a reduction in the amount of liquid diet consumed. When compared to pair fed controls, rats fed the ethanol-containing diet showed marked changes in skeletal muscle. These observations are similar to those in man and we conclude that the use of the Lieber-De Carli feeding regime in experimental animals is a suitable means of investigating the mechanism of skeletal myopathy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0735-0414
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
151-4
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
Biological effects of chronic ethanol consumption: a reappraisal of the Lieber-De Carli liquid-diet model with reference to skeletal muscle.
|
| pubmed:affiliation |
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K.
|
| pubmed:publicationType |
Journal Article,
Review
|