Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1988-8-4
|
pubmed:abstractText |
Central and lateral hypothalamic concentrations of 10 regulatory peptides were measured by radioimmunoassay in streptozocin-induced diabetic (STZ-D) and matched control rats between 1 day and 14 wk after diabetes induction. After 2 wk, both central and lateral hypothalamic neuropeptide Y (NPY) concentrations in STZ-D rats were consistently higher than those found in control rats, with significant 30-50% increases at 4 wk in the central hypothalamus, and at 6 and 14 wk in both central and lateral hypothalamus. Immunocytochemical studies in 4- and 6-wk STZ-D animals showed the appearance of intensely NPY-positive swollen cell bodies in the supraoptic nucleus and a subjective increase in NPY staining of medial hypothalamic nerve fibers. Central hypothalamic concentrations of three other peptides were significantly greater in STZ-D animals than those in control animals at single points (neurotensin, 1 day; calcitonin gene-related peptide, 2 wk; neurokinin, 4 wk). Hypothalamic concentrations of the other six peptides examined (bombesin, galanin, neuromedin B, substance P, somatostatin, and vasoactive intestinal peptide) did not differ significantly between STZ-D and control groups at any time. However, galanin immunostaining in the supraoptic and magnocellular paraventricular nuclei was strikingly concentrated in a reduced number of distended cell bodies. Hypothalamic peptide changes in STZ-D could be related to metabolic disturbance, changes in energy and water balance, altered pituitary function, or other factors. Persistently elevated concentrations of NPY, a very potent central stimulant of eating and drinking, may mediate the hyperphagia and polydipsia characteristic of STZ-D.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0012-1797
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
37
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
763-72
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3289997-Animals,
pubmed-meshheading:3289997-Diabetes Mellitus, Experimental,
pubmed-meshheading:3289997-Drinking Behavior,
pubmed-meshheading:3289997-Feeding Behavior,
pubmed-meshheading:3289997-Hypothalamus,
pubmed-meshheading:3289997-Immunoenzyme Techniques,
pubmed-meshheading:3289997-Male,
pubmed-meshheading:3289997-Neurons,
pubmed-meshheading:3289997-Neuropeptide Y,
pubmed-meshheading:3289997-Neuropeptides,
pubmed-meshheading:3289997-Radioimmunoassay,
pubmed-meshheading:3289997-Rats,
pubmed-meshheading:3289997-Rats, Inbred Strains
|
pubmed:year |
1988
|
pubmed:articleTitle |
Increased hypothalamic neuropeptide Y concentrations in diabetic rat.
|
pubmed:affiliation |
Francis Fraser Laboratories, Department of Medicine, Royal Postgraduate Medical School, London, United Kingdom.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|