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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1988-7-12
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pubmed:abstractText |
The influence of IL-1 administration on the recovery of the hemopoietic and immune systems from sublethal irradiation was assessed. Mice were irradiated (750 R) and injected twice daily with purified recombinant derived IL-1 beta (200 ng/injection). At various times after irradiation, the functional capacity of the hemopoietic and immune systems was determined. It was found that IL-1 therapy resulted in a significantly greater number of granulocyte-macrophage-CSF responsive colony-forming cells in the bone marrow of the irradiated mice on days 5 and 11 postirradiation but not at later times. In addition the radiation induced neutropenia recovered quicker in the IL-1-treated mice with significantly greater numbers of peripheral blood granulocytes being seen on days 15 and 20 after irradiation. The influence of IL-1 therapy on the recovery of the immune system was also assessed. Of note was the observation that mice receiving IL-1 therapy had chronically hypoplastic thymi. Although thymic cellularity increased with time after irradiation in the control mice, there was no such increase in the IL-1-treated mice. Similarly, the number of pre-B cells in the marrow of these mice was also diminished. Thus, in the IL-1-treated mice the regeneration of the peripheral immune function was retarded, characterized by a general lymphopenia and decreased splenic responses to mitogenic stimuli.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4204-10
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3286769-Animals,
pubmed-meshheading:3286769-Bone Marrow,
pubmed-meshheading:3286769-Female,
pubmed-meshheading:3286769-Hematopoiesis,
pubmed-meshheading:3286769-Immunity, Cellular,
pubmed-meshheading:3286769-Interleukin-1,
pubmed-meshheading:3286769-Leukocyte Count,
pubmed-meshheading:3286769-Lymphocyte Activation,
pubmed-meshheading:3286769-Mice,
pubmed-meshheading:3286769-Mice, Inbred C57BL,
pubmed-meshheading:3286769-Regeneration,
pubmed-meshheading:3286769-Spleen,
pubmed-meshheading:3286769-Whole-Body Irradiation
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pubmed:year |
1988
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pubmed:articleTitle |
The influence of IL-1 treatment on the reconstitution of the hemopoietic and immune systems after sublethal radiation.
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pubmed:affiliation |
Immunex Corporation, Seattle, WA 98101.
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pubmed:publicationType |
Journal Article
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