rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1988-7-12
|
pubmed:abstractText |
To determine whether opioid peptides have direct effects on myocardium we compared the effects of enkephalin analogs DAGO and DADL on both an innervated heart and a denervated heterotopically transplanted heart in the same animal. DAGO and DADL injected intravenously into anesthetized rats with two hearts produced hypotension, fall in end-systolic left ventricular pressure of both recipient's and donor's heart, bradycardia and decreasing of contractility in recipient's heart. Opioid peptides exerted no chronotropic effect and a slight positive inotropic effect on denervated transplanted heart. Both bradycardia and decreasing of contractility in recipient's heart have the neurogenic origin.
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pubmed:language |
rus
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0015-329X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
74
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
269-75
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3286295-Abdomen,
pubmed-meshheading:3286295-Animals,
pubmed-meshheading:3286295-Denervation,
pubmed-meshheading:3286295-Endorphins,
pubmed-meshheading:3286295-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:3286295-Enkephalin, Leucine,
pubmed-meshheading:3286295-Enkephalin, Leucine-2-Alanine,
pubmed-meshheading:3286295-Enkephalins,
pubmed-meshheading:3286295-Heart,
pubmed-meshheading:3286295-Heart Catheterization,
pubmed-meshheading:3286295-Heart Transplantation,
pubmed-meshheading:3286295-Hemodynamics,
pubmed-meshheading:3286295-Isoproterenol,
pubmed-meshheading:3286295-Male,
pubmed-meshheading:3286295-Propranolol,
pubmed-meshheading:3286295-Rats,
pubmed-meshheading:3286295-Rats, Inbred Strains
|
pubmed:year |
1988
|
pubmed:articleTitle |
[Effects of opioid peptides on rats with a second heart transplanted into the abdominal cavity].
|
pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|