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pubmed-article:3285377pubmed:abstractTextThe crude rat and bovine synaptosomal lysate from brain can hydrolyze angiotensin I (AI) to des-Leu angiotensin I (AI-dL) and no further. This cytosolic enzyme has a specificity for angiotensin-related sequences, R-His-Pro-Phe-His-Leu and therefore named angiotensin-related carboxypeptidase (ARC). These studies led to the biosynthesis and purification of AI-dL in order to determine if it can provoke a drinking response. This nonapeptide is a potent dipsogen when injected into the cerebroventricles of rats. The drinking response probably requires a second hydrolysis to angiotensin II (AII) since both captopril and saralasin can inhibit this response.lld:pubmed
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pubmed-article:3285377pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:3285377pubmed:articleTitleDes-Leu angiotensin I: biosynthesis and drinking response.lld:pubmed
pubmed-article:3285377pubmed:affiliationUniversity of Louisville School of Medicine, Health Sciences Center, KY 40292.lld:pubmed
pubmed-article:3285377pubmed:publicationTypeJournal Articlelld:pubmed
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