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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-6-20
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pubmed:abstractText |
The crude rat and bovine synaptosomal lysate from brain can hydrolyze angiotensin I (AI) to des-Leu angiotensin I (AI-dL) and no further. This cytosolic enzyme has a specificity for angiotensin-related sequences, R-His-Pro-Phe-His-Leu and therefore named angiotensin-related carboxypeptidase (ARC). These studies led to the biosynthesis and purification of AI-dL in order to determine if it can provoke a drinking response. This nonapeptide is a potent dipsogen when injected into the cerebroventricles of rats. The drinking response probably requires a second hydrolysis to angiotensin II (AII) since both captopril and saralasin can inhibit this response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0167-0115
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3285377-Angiotensin I,
pubmed-meshheading:3285377-Angiotensin II,
pubmed-meshheading:3285377-Animals,
pubmed-meshheading:3285377-Brain,
pubmed-meshheading:3285377-Captopril,
pubmed-meshheading:3285377-Carboxypeptidases,
pubmed-meshheading:3285377-Cattle,
pubmed-meshheading:3285377-Drinking,
pubmed-meshheading:3285377-Male,
pubmed-meshheading:3285377-Rats,
pubmed-meshheading:3285377-Rats, Inbred Strains,
pubmed-meshheading:3285377-Saralasin,
pubmed-meshheading:3285377-Synaptosomes
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pubmed:year |
1988
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pubmed:articleTitle |
Des-Leu angiotensin I: biosynthesis and drinking response.
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pubmed:affiliation |
University of Louisville School of Medicine, Health Sciences Center, KY 40292.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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