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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1988-6-7
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pubmed:abstractText |
Tetra benzamidine derivatives were found to inhibit proteinase activity, cell proliferation and accumulation of the Ha-ras-1 mRNA in the FHO6T1-1 Chinese Hamster cell line, transformed with the activated human T24-Ha-ras-1 oncogene. Di- and Tri-benzamidine derivatives were also found to be potent inhibitors of proliferation of FHO6T1-1 cells. These latter compounds could be proposed as useful substrates in the synthesis of drug-conjugated monoclonal antibodies or growth factors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3284453-Amidines,
pubmed-meshheading:3284453-Animals,
pubmed-meshheading:3284453-Antibodies, Monoclonal,
pubmed-meshheading:3284453-Benzamidines,
pubmed-meshheading:3284453-Cell Line,
pubmed-meshheading:3284453-Cricetinae,
pubmed-meshheading:3284453-Cricetulus,
pubmed-meshheading:3284453-Genes, ras,
pubmed-meshheading:3284453-Microscopy, Electron, Scanning,
pubmed-meshheading:3284453-RNA, Messenger
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pubmed:articleTitle |
Effects of benzamidine derivatives on Ha-ras-1 mRNA accumulation in a Chinese hamster cell line transformed with the activated human T24 Ha-ras-1 oncogene.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Universitá di Ferrara, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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