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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-6-9
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pubmed:abstractText |
The simple reversible intercalating agent isopropyl-OPC (iPr-OPC) induces frameshift-1 mutations in Salmonella typhimurium and Escherichia coli. The mutagenic responses of S. typhimurium and E. coli wild-type strains are not proportional to the amount of drug intercalated into double-stranded nucleic acids in living bacteria; it occurs only above a minimum level of binding. The fact that mismatch-repair-deficient (mutS) as well as adenine-methylation-deficient (dam) E. coli mutants are hypermutable at low concentrations of iPr-OPC suggests that the majority of mutants induced by this intercalating drug occur as mismatch-repairable mutations (or lesions) in the newly synthesized DNA strand close to the replication fork.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-5107
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
193
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3283540-Alkaloids,
pubmed-meshheading:3283540-Bacterial Proteins,
pubmed-meshheading:3283540-DNA, Bacterial,
pubmed-meshheading:3283540-DNA Damage,
pubmed-meshheading:3283540-DNA Repair,
pubmed-meshheading:3283540-Ellipticines,
pubmed-meshheading:3283540-Escherichia coli,
pubmed-meshheading:3283540-Methyltransferases,
pubmed-meshheading:3283540-Mutation,
pubmed-meshheading:3283540-Site-Specific DNA-Methyltransferase (Adenine-Specific)
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pubmed:year |
1988
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pubmed:articleTitle |
Frameshift lesions induced by oxazolopyridocarbazoles are recognized by the mismatch repair system in Escherichia coli.
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pubmed:affiliation |
Laboratoire de Biochimie-Enzymologie, INSERM U140, CNRS UA147, Institut Gustave Roussy, Villejuif, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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