|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1977-9-17
|
|
pubmed:abstractText |
Because of its chiralic alpha-phosphorus atom adenosine 5'-O-(1-thiotriphosphate) (ATPalphaS) exists in two diastereomeric forms, arbitrarily named (A) and (B). For phenylalanyl-tRNA synthetase ATPalphaS (A) is a substrate whereas ATPalphaS (B) is neither a substrate nor an inhibitor. During the ATPalphaS (A)/PPi exchange reaction with phenylalanyl-tRNA synthetase the configuration at the alpha-phosphorus is retained. The mechanistic implications of these findings are discussed. Preliminary investigations with several other aminoacyl-tRNA synthetases show that the stereochemical requirement with respect to the alpha-phosphorus of ATP is not identical for all aminoacyl-tRNA synthetases.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0014-2956
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
76
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
263-7
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:328281-Adenosine Triphosphate,
pubmed-meshheading:328281-Amino Acyl-tRNA Synthetases,
pubmed-meshheading:328281-Chemical Phenomena,
pubmed-meshheading:328281-Chemistry,
pubmed-meshheading:328281-Chromatography, High Pressure Liquid,
pubmed-meshheading:328281-Kinetics,
pubmed-meshheading:328281-Molecular Conformation,
pubmed-meshheading:328281-Phenylalanine,
pubmed-meshheading:328281-Phenylalanine-tRNA Ligase,
pubmed-meshheading:328281-Saccharomyces cerevisiae,
pubmed-meshheading:328281-Stereoisomerism,
pubmed-meshheading:328281-Structure-Activity Relationship,
pubmed-meshheading:328281-Thionucleotides,
pubmed-meshheading:328281-Transfer RNA Aminoacylation
|
|
pubmed:year |
1977
|
|
pubmed:articleTitle |
On the stereochemistry of activation of phenylalanine by phenylalanyl-tRNA synthetase from baker's yeast.
|
|
pubmed:publicationType |
Journal Article
|
