Linked Life Data

3280676

Source:http://linkedlifedata.com/resource/pubmed/id/3280676

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-4-22
pubmed:abstractText
The aim was to investigate the contribution of the kidneys and the extrarenal tissues to the concentration of inactive renin in the circulation. Renin was determined in plasma from normal, conscious, male mice in strains with low (BALB/c) and high (Theiller) renin content in the submandibular glands. In untreated, conscious males, inactive and active renin concentration in plasma was 24.9 GU/l (range 13.6-40.1 GU/l) and 4.2 GU/l (0.6-8.8 GU/l), respectively in the BALB/c strain (n = 28). These values were not significantly different from the concentrations of inactive (29.2 GU/l, range 15.6-88.3 GU/l) and active (5.1 GU/l, range 1.9-10.4 GU/l) renin in Theiller's strain (n = 10). Thus, inactive renin comprised 80-90% of the total renin in plasma from normal, conscious, male mice of both strains. The percentage of inactive renin was similar to that found in humans. Following sialo-adenectomy and bilateral nephrectomy, the plasma concentration of inactive renin was unchanged. The effect of in vivo inhibition of the protein synthesis by intraperitoneal injection of emetine was also investigated. After 6 h of inhibition, inactive renin in plasma declined from 21.0 to 9.9 GU/l in normal mice. In contrast, inactive renin was unchanged in sialo-adenectomized and nephrectomized mice (29.1 versus 28.6 GU/l). Our findings suggest that the kidneys are the main source of inactive renin in the circulation. The data also indicate that the kidneys simultaneously secrete and remove inactive renin from the blood at approximately the same rate.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0263-6352
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-37
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Evidence for a predominant renal secretion and clearance of inactive plasma renin, studied by in vivo inhibition of protein synthesis.
pubmed:affiliation
Institute of Biochemistry, Royal Dental College, Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't