Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1976-5-10
pubmed:abstractText
A 4-month double-blind study comparing the effect of increasing oral doses (up to 1.0 g daily) of synthetic L-proyl-L-leucyl-glycine amide (PLG) and placebo in 20 parkinsonian patients showed no significant improvement in objective scores of functional disability. However, important trends and some significant results were observed with the lower doses of PLG. These essentially negative results may be attributed to poor intestinal absorption of the compound, a short biologic half-life in the blood, or administration of oral doses that were much higher than required, or a combination of factors. In further studies with this peptide, which are encouraged, the intravenous route should be used until the question of intestinal absorption is resolved.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-238221, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4125041, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4140382, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4216256, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4364044, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4398196, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4610443, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4614981, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4633626, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4640811, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4746492, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4837910, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4858836, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-4947365, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-5064701, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-5283931, http://linkedlifedata.com/resource/pubmed/commentcorrection/3279-5820999
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0008-4409
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-2
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Double-blind evaluation of oral L-prolyl-Lleucyl-glycine amide in Parkinson's disease.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial