Linked Life Data

3279716

Source:http://linkedlifedata.com/resource/pubmed/id/3279716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-4-14
pubmed:abstractText
Airway closure, mean airway pressure, gas exchange and different modes of artificial ventilation were investigated in anesthetized and paralyzed dogs with clinically healthy lungs. The animals were ventilated with either intermittent positive pressure ventilation (IPPV), continuous positive pressure ventilation (GPPV, positive end-expiratory pressure (PEEP) = 0.49 kPa) or high-frequency jet ventilation (HFJV, open system) of 2 and 30 Hz with an inspiratory to expiratory (I/E) - ratio of 30/70 and 60/40. Closing volume (CV) was determined by a modified technique, submitting the lung to constant subatmospheric pressure after an inspiratory vital capacity of oxygen. Two different tests for CV were used: the foreign gas bolus (FGB) with helium as nonresident gas and the single breath nitrogen dilution technique (SBO2). During conventional mechanical ventilation, CV decreased significantly (P less than 0.05) after establishing a PEEP of 0.49 kPa. During HFJV, CV increased significantly (P less than 0.01). This effect was predominantly dependent on I/E duration time ratio and to a lesser extent on ventilatory frequency. There were significant differences between CV obtained by the FGB-method (CV(helium] and CV derived from the SBO2-test (CV(SBO2], although both tests revealed the same proportional changes of CV during the different modes of ventilation. The elevated CV was associated with a decreasing Pao2 and increasing Aa-Do2 and Paco2, indicating substantial hypoventilation and mismatching of ventilation and perfusion. Mean airway pressure increased with both CPPV and HFJV, revealing a dissociation between airway pressure and regional FRC distribution during HFJV. It is concluded that certain modes of high-frequency ventilation lead to impaired distribution of inspired gas to dependent lung regions.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0001-5172
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
140-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
"Closing volume" during high-frequency ventilation in anesthetized dogs.
pubmed:affiliation
Department of Anesthesiology and Intensive Care, Westfälische Wilhelms-Universität Münster, FRG.
pubmed:publicationType
Journal Article