Linked Life Data

3276385

Source:http://linkedlifedata.com/resource/pubmed/id/3276385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-3-14
pubmed:abstractText
This article describes the use of panels of antibodies in the histopathologic diagnosis of ten malignant melanomas arising in the mucosa of the head and neck. The immunohistochemistry analysis was performed in a step-by-step manner. In the first step a panel of antibodies discriminating between carcinoma, malignant lymphoma, and melanoma was used. Staining with antivimentin and the melanoma-associated antigen, moAb NKI/C-3, was found to occur in all cases. The NKI/C-3 stained nine of 10 specimens from the first biopsy. Anti-S-100 protein, anti-HMW-MAA, and NKI-beteb was used as a panel in the second step. These stained ten of ten, five of six, and seven of seven cases, respectively. The diagnosis for melanin was confirmed by extensive sampling and a diligent search for melanin and (pre)melanosomes in different biopsy and surgical specimens. These results indicate that a step-wise application of immunohistochemistry is a very useful tool in the diagnosis of mucosal melanoma of the head and neck.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-543X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
702-11
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Diagnostic application of panels of antibodies in mucosal melanomas of the head and neck.
pubmed:affiliation
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article