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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1990-3-9
|
| pubmed:abstractText |
C21H21N3O5, Mr = 395.42, orthorhombic, P2(1)2(1)2(1), a = 5.935 (2), b = 13.037 (1), c = 25.992 (2) A, V = 2011 (1) A3, Z = 4, D chi = 1.31 Mg m-3, lambda(Cu K alpha) = 1.5418 A, mu = 0.74 mm-1, F(000) = 832, room temperature, final R = 0.046 for 1343 observed reflections. The title compound adopts a type II' beta-turn conformation in the solid state, stabilized by a 4----1 intramolecular hydrogen bond between the CO of the protecting benzyloxycarbonyl group and the NH2 of the terminal amide group. These results indicate that the beta-turn conformation, already found in the solid state for peptides embodying the sequence Asu-Gly or Asu-Ala, is highly preferred, even when the residue next to the aminosuccinyl moiety has a bulkier side chain. In the crystal, rows of hydrogen-bonded molecules are held together by van der Waals forces between hydrophobic phenyl groups.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0108-2701
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
44 ( Pt 5)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
880-2
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| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
N-benzyloxycarbonyl-L-aminosuccinyl-L-phenylalaninamide (Z-L-Asu-L-Phe-NH2).
|
| pubmed:affiliation |
Dipartimento di Chimica, Università, Napoli, Italy.
|
| pubmed:publicationType |
Journal Article
|