Linked Life Data

3268114

Source:http://linkedlifedata.com/resource/pubmed/id/3268114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-12-20
pubmed:abstractText
Carcinogenic risk assessment based on low-dose extrapolation of dose-response relationships is characterized by a significant level of uncertainty. The aim of this study was to investigate the reproducibility of risk estimates carried out using different animal species and strains. The Weibull and multistage mathematical modes, as well as the "linearized multistage" model (EPA "conservative" procedure), have been used for dose-response relationship fitting. Whenever necessary, the Michaelis-Menten function was introduced in the models to account for a possible metabolic process. The analysis was directed to dietary sodium saccharin and vinyl chloride inhalation carcinogenicity (nine total dose-response relationships). Data from different strains, species, and researchers were available for these substances. The general pattern of two sodium saccharin curves was an upward curve in both cases with a high consistency among parameters and risk estimates (the latter ranging within a factor 3). For vinyl chloride the trend was clearly downward for six carcinogenic dose-response relationships from different species; low-dose risk estimates, based on the upper confidence limits of the linear component, range within a factor 3. The study has indicated the reproducibility of the low-dose extrapolation process using different strains and species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0895-3988
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Reproducibility of low-dose extrapolation procedure: comparison of estimates obtained using different rodent species and strains.
pubmed:affiliation
Istituto Superiore di Sanità, Rome, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't