Linked Life Data

3268039

Source:http://linkedlifedata.com/resource/pubmed/id/3268039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 4
pubmed:dateCreated
1989-11-6
pubmed:abstractText
Nine families were examined for linkage on chromosome 1 between the hypervariable gene PUM and the alpha-spectrin (SPTA) gene using DNA probes. Close linkage was found with a maximum lod score of 5.98 at theta = 0.05. Hybridization to DNA from somatic cell hybrids made from a parent line carrying a balanced X:1 translocation showed both genes to lie proximal to the breakpoint at 1q23. DNA hybridization to cell lines carrying deletions of 1q21-25 showed the presence of two polymorphic alleles for both loci. These results, combined with existing in situ hybridization data, suggest PUM and SPTA both lie within 1q21. Linkage analysis between PUM and the Duffy blood group (FY) gave a maximum lod of 2.15 at theta = 0.15. These data combined with data from another laboratory give a maximum lod of 5.21 for linkage between PUM and FY at theta = 0.10.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Close linkage of PUM and SPTA within chromosome band 1q21.
pubmed:affiliation
Mothercare Department of Paediatric Genetics, Institute of Child Health, London.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't