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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-9-5
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pubmed:abstractText |
Sera of patients with primary myelofibrosis (PMF), primary thrombocythemia (PT), polycythaemia vera (PV) and chronic myeloid leukemia (CML) contained a significantly increased F-CSA (or F-CSAs) compared to those of normal subjects and patients with secondary thrombocytosis (ST). This F-CSA was heat sensitive and had the capacity to promote both proliferation and maturation of normal marrow fibroblast colony-forming cells (CFU-F). This F-CSA seemed to be different from human platelet derived growth factor (PDGF), tumor necrosis factor (TNF) and fibroblast growth factor (FGF) from bovine brain. This F-CSA might be of importance in the pathogenesis of bone marrow fibrosis in myeloproliferative disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0393-974X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-24
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3267102-Animals,
pubmed-meshheading:3267102-Bone Marrow Cells,
pubmed-meshheading:3267102-Cattle,
pubmed-meshheading:3267102-Cell Division,
pubmed-meshheading:3267102-Colony-Forming Units Assay,
pubmed-meshheading:3267102-Colony-Stimulating Factors,
pubmed-meshheading:3267102-Fibroblast Growth Factors,
pubmed-meshheading:3267102-Fibroblasts,
pubmed-meshheading:3267102-Hot Temperature,
pubmed-meshheading:3267102-Humans,
pubmed-meshheading:3267102-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:3267102-Myeloproliferative Disorders,
pubmed-meshheading:3267102-Platelet-Derived Growth Factor,
pubmed-meshheading:3267102-Polycythemia Vera,
pubmed-meshheading:3267102-Primary Myelofibrosis,
pubmed-meshheading:3267102-Stem Cells,
pubmed-meshheading:3267102-Thrombocythemia, Essential,
pubmed-meshheading:3267102-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Increased fibroblast colony stimulating activity (F-CSA) in serum of myeloproliferative disorders.
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pubmed:affiliation |
Department of Hematology, A. Morvan Hospital, Brest University School of Medicine, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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