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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1989-8-25
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pubmed:abstractText |
Activated peripheral T cells (APT) of patients with Crohn's disease (CD) have been analysed for the expression of IgA-Fc receptors and for competence of IgA regulation. It was found that within the subset of APT an increased number of cells express binding sites for IgA (IgA-Fc), that was not found in other diseases with elevated numbers of APT. Moreover the number of IgA-Fc receptor expressing T cells was found to be increased in the inflamed mucosa too. Cocultures with autologous B cells revealed that isolated IgA-Fc receptor bearing T cells of patients with CD suppress IgA secretion. These data support the hypothesis that APT are involved in the immunopathogenesis of CD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0065-2598
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
665-73
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3267066-Antibodies, Monoclonal,
pubmed-meshheading:3267066-Antigens, CD,
pubmed-meshheading:3267066-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3267066-B-Lymphocytes,
pubmed-meshheading:3267066-Cells, Cultured,
pubmed-meshheading:3267066-Crohn Disease,
pubmed-meshheading:3267066-Humans,
pubmed-meshheading:3267066-Immunoglobulin A,
pubmed-meshheading:3267066-Intestinal Mucosa,
pubmed-meshheading:3267066-Lymphocyte Activation,
pubmed-meshheading:3267066-Receptors, Fc,
pubmed-meshheading:3267066-T-Lymphocytes
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pubmed:year |
1988
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pubmed:articleTitle |
Activated Fc alpha T cells in Crohn's disease are involved in regulation of IgA.
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pubmed:affiliation |
Med. Dept. Univ., Hamburg, FRG.
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pubmed:publicationType |
Journal Article
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