Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-4-4
pubmed:databankReference
pubmed:abstractText
Human pregnancy-specific beta 1-glycoprotein (SP1) plays an essential role in normal pregnancy. It is also a well-characterized oncodevelopmental antigen, expressed aberrantly by all trophoblastic tumors and some other malignant cell types. Here we report the identification of a human placental cDNA encoding the SP1 polypeptide sequence. The coding sequence shows 95% identity at the nucleotide level with a distinct, recently published SP1 cDNA sequence (PSG16). Unexpectedly, the sequence is also highly homologous to the published sequence of human carcinoembryonic antigen (CEA). SP1, CEA and CEA-related nonspecific cross-reacting species thus belong to a group of closely related though antigenically diverse tumor-associated glycoproteins. Comparison of the deduced amino acid sequence of the SP1 cDNA with that of CEA provides insight into the modular nature of these related proteins. This may have implications for the genomic organization and evolution of the CEA gene family.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
439-49
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:3265688-Amino Acid Sequence, pubmed-meshheading:3265688-Antigens, Neoplasm, pubmed-meshheading:3265688-Base Sequence, pubmed-meshheading:3265688-Blotting, Northern, pubmed-meshheading:3265688-Blotting, Southern, pubmed-meshheading:3265688-Carcinoembryonic Antigen, pubmed-meshheading:3265688-Cell Adhesion Molecules, pubmed-meshheading:3265688-Cloning, Molecular, pubmed-meshheading:3265688-DNA, pubmed-meshheading:3265688-Female, pubmed-meshheading:3265688-Glycoproteins, pubmed-meshheading:3265688-Humans, pubmed-meshheading:3265688-Molecular Sequence Data, pubmed-meshheading:3265688-Oligonucleotide Probes, pubmed-meshheading:3265688-Pregnancy, pubmed-meshheading:3265688-Pregnancy Proteins, pubmed-meshheading:3265688-Pregnancy-Specific beta 1-Glycoproteins, pubmed-meshheading:3265688-Sequence Homology, Nucleic Acid, pubmed-meshheading:3265688-Trypsin
pubmed:year
1988
pubmed:articleTitle
Molecular cloning of a cDNA for human pregnancy-specific beta 1-glycoprotein:homology with human carcinoembryonic antigen and related proteins.
pubmed:affiliation
Department of Biochemistry, University of Aberdeen, Marischal College, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't