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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-3-29
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pubmed:abstractText |
We have examined some of the factors which may regulate the generation and function of human lymphokine-activated killer (LAK) cells. In particular we have studied the effect of cytokines other than interleukin-2 on the ability of human LAK cells to kill human tumour cells. By exposing human tumour cells to human LAK-cells in the presence and absence of interleukin-3 or interleukin-4, we were able to demonstrate that each of these cytokines was able to severely reduce the amount of tumour cell killing. Additionally, we examined the effect of interleukin-3 or interleukin-4 on the production in vitro of human LAK cells by including these materials with interleukin-2 while LAK-cells were being induced. These results showed that not only were these cytokines able to inhibit human LAK-cell function, but they were also able to strongly reduce the ability of interleukin-2 to generate human LAK-cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-2958930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3037082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3076761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3083412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3100627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3299346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3495566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3497196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3498002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3500227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3518753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3538818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265653-3547026
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
166-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3265653-Animals,
pubmed-meshheading:3265653-Cytotoxicity, Immunologic,
pubmed-meshheading:3265653-Dose-Response Relationship, Drug,
pubmed-meshheading:3265653-Humans,
pubmed-meshheading:3265653-Interleukin-3,
pubmed-meshheading:3265653-Interleukin-4,
pubmed-meshheading:3265653-Interleukins,
pubmed-meshheading:3265653-Killer Cells, Natural,
pubmed-meshheading:3265653-Leukocyte Count,
pubmed-meshheading:3265653-Leukocytes,
pubmed-meshheading:3265653-Mice,
pubmed-meshheading:3265653-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
Interleukin-3 and interleukin-4 each strongly inhibit the induction and function of human LAK cells.
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pubmed:affiliation |
Immunology Division, University of Strathclyde, Glasgow.
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pubmed:publicationType |
Journal Article
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