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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-3-17
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pubmed:abstractText |
Four peptides derived from procalcitonin were isolated in high yield from an extract of a human medullary thyroid carcinoma. The peptides were identified as procalcitonin-(1-57)-peptide, procalcitonin-(60-91)-peptide (calcitonin), procalcitonin-(60-116)-peptide and procalcitonin-(96-116)-peptide (katacalcin). Determination of the amino acid sequence of procalcitonin-(1-57)-peptide has demonstrated that the Ala25-Ala26 bond in preprocalcitonin is the site of cleavage of the signal peptide. Procalcitonin-(60-116)-peptide represents calcitonin extended from its C-terminus by the sequence Gly-Lys-Lys-Arg-katacalcin, and its formation is indicative of an aberrant pathway of procalcitonin processing in the tumour cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-2408883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-2865169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-2891188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-2893603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3000586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3411280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3485540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3489641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3490472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3492393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3516723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3545904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3872459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-3967626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-4370934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6102950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6114953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6199352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-621283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6258582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6267096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6546550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6609312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6610687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6611278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-6861143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-7057900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-7228999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265620-7409186
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Structural characterization of a high-molecular-mass form of calcitonin [procalcitonin-(60-116)-peptide] and its corresponding N-terminal flanking peptide [procalcitonin-(1-57)-peptide] in a human medullary thyroid carcinoma.
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pubmed:affiliation |
Klinische Arbeitsgruppe für Gastrointestinale Endokrinologie, Max-Planck-Gesellschaft, Universität Göttingen.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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