Linked Life Data

3265403

Source:http://linkedlifedata.com/resource/pubmed/id/3265403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1989-3-23
pubmed:abstractText
The present study shows that the distribution of T lymphocytes in gastrointestinal carcinomas and their metastases mimic the distribution of T lymphocytes in normal intestine. The composition of the peritumoral reaction resembled that of normal lamina propria with a predominance of CD3 + CD4 + T cells. In contrast, lymphocytes located between carcinomatous cells showed phenotypical features similar to those of intraepithelial lymphocytes (IEL) in normal intestine; in particu(abstractlar they expressed the antigen defined by HML-1, a monoclonal antibody raised against normal human intestinal IEL which reveals 95% IEL but very few cells in lymphoid (abstractorgans and blood. As normal intestinal IEL, the majority of intratumoral lymphocytes had the CD3+ CD8+ phenotype. A panel of monoclonal antibodies and double immunostaining techniques permitted a better characterisation of minor subsets of IEL. Two subsets of HML1 + CD3 + CD4- CD8- and of HML1+ CD3- cells, representing 2% and 3% of normal intestinal IEL respectively, did not significantly increase in carcinomatous epithelium. In contrast, in carcinomatous epithelium, but not in normal intestinal epithelium, we observed the appearance of a few lymphocytes displaying the phenotype of activated T cells (CD25+) or of natural killer cells (NKHI+) or of suppressor cells (CD11+). Such cells may participate in antitumoral defence. Although a similar population of HML1+ lymphocytes is associated with normal and carcinomatous intestinal epithelium, some interactions between lymphocytes and epithelial cells may not be maintained in tumoral epithelium. It has previously been shown that HLA-DR expression by enterocytes is modulated by intraepithelial lymphocytes. In our study, no correlation could be shown between the degree of lymphocytic infiltration and the expression of HLA-DR antigens on carcinomatous cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-2425030, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-2873198, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3102967, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3105871, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-31410, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3305585, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3362141, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-338444, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3486193, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3491776, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3498635, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3525341, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-3871194, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-6425398, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-6687894, http://linkedlifedata.com/resource/pubmed/commentcorrection/3265403-77279
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1632-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Same peculiar subset of HML1 + lymphocytes present within normal intestinal epithelium is associated with tumoral epithelium of gastrointestinal carcinomas.
pubmed:affiliation
INSERM U239, Faculté de Médecine Xavier Bichat, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't