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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-3-9
|
| pubmed:abstractText |
We have determined alpha+ deletional thalassemia among 143 Southeast Asia refugees (Cambodians, Laotians, and Vietnameses). Gene frequency of alpha+ deletional thalassemia in Vietnameses (0.035) was found lower than in Cambodians and Laotians (0.11). Bam H1 and Bg1 II analysis indicated that both rightward and leftward thalassemias are encountered, the -alpha 3,7 form is being by far more frequent than the -alpha 4.2 one. Only type I cross-over was found by Apa I digestion on -alpha 3.7 chromosomes. The Rsa I polymorphism, 5' to Z alpha 2 block, is associated with -alpha 3.7 type I haplotype and the site is present in 12 out of 23 chromosomes. All these data suggest at least three origins of alpha+-thalassemia in Cambodia and Laos.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0003-3995
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
201-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3265302-Asia, Southeastern,
pubmed-meshheading:3265302-Chromosome Deletion,
pubmed-meshheading:3265302-Gene Frequency,
pubmed-meshheading:3265302-Haplotypes,
pubmed-meshheading:3265302-Humans,
pubmed-meshheading:3265302-Polymorphism, Genetic,
pubmed-meshheading:3265302-Thalassemia
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Types of alpha+ thalassemia in Southeast Asia refugees.
|
| pubmed:affiliation |
INSERM U 15, CHU Cochin, Paris.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|