|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010658,
umls-concept:C0071744,
umls-concept:C0086418,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0678594,
umls-concept:C0679058,
umls-concept:C0680022,
umls-concept:C1519249,
umls-concept:C1547699,
umls-concept:C1883220,
umls-concept:C2347858,
umls-concept:C2700640
|
|
pubmed:dateCreated |
1989-2-7
|
|
pubmed:abstractText |
The human cystatin C gene was cloned using a synthetic oligonucleotide predicted from a portion of its amino-acid sequence. The nucleotide sequence of the restriction fragment hybridizing with the oligonucleotide confirms the existence of one exon encoding amino acids 56-93 of human cystatin C and its relationship to kininogens. However the deduced amino-acid sequence differs in one position from the sequence of the cystatin C fragment deposited as amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of icelandic origin.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0177-3593
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
369 Suppl
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
205-8
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:3264504-Base Sequence,
pubmed-meshheading:3264504-Cystatin C,
pubmed-meshheading:3264504-Cystatins,
pubmed-meshheading:3264504-Cysteine Proteinase Inhibitors,
pubmed-meshheading:3264504-DNA,
pubmed-meshheading:3264504-Humans,
pubmed-meshheading:3264504-Molecular Sequence Data,
pubmed-meshheading:3264504-Nucleic Acid Hybridization,
pubmed-meshheading:3264504-Oligonucleotides,
pubmed-meshheading:3264504-Protease Inhibitors,
pubmed-meshheading:3264504-Protein Biosynthesis
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Isolation of a sequence encoding human cystatin C. Conservation of exon-intron structure between members of the cysteine proteinase inhibitors superfamily.
|
|
pubmed:affiliation |
Department of Pathology, New York University Medical Center, New York.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
