|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021034,
umls-concept:C0023418,
umls-concept:C0080194,
umls-concept:C0205197,
umls-concept:C0205419,
umls-concept:C0312738,
umls-concept:C0376249,
umls-concept:C0591833,
umls-concept:C1511695,
umls-concept:C1517162,
umls-concept:C1704689
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1989-1-17
|
|
pubmed:abstractText |
Fetal liver Abelson pre-B cell lines obtained from CBA/Tufts.xid and (CBA/Tufts.xid x CBA/Tufts)F1 mice have complete VDJH rearrangements on at least one allele. Such high frequencies of VDJH rearrangements have previously been observed in adult derived but not fetal liver derived Abelson pre-B cell lines. Genetic analyses suggest that CBA/Tufts.xid carries an autosomal dominant gene(s) that determines the predominance of VDJH rearrangements among transformants. This autosomal gene(s) might affect the intrinsic development of the early B cell lineage in the fetus or the fetal microenvironment, expanding pre-B cells of the "more mature" VDJH phenotype.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-178822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-2824191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-3093247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-3096716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-3110357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-3494095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-3975629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6086308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6092095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6092962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6257398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6277505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6300689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6381637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6434687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6722869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6775817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264321-6801182
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
168
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2023-30
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3264321-Abelson murine leukemia virus,
pubmed-meshheading:3264321-Animals,
pubmed-meshheading:3264321-B-Lymphocytes,
pubmed-meshheading:3264321-Cell Transformation, Viral,
pubmed-meshheading:3264321-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:3264321-Genetic Linkage,
pubmed-meshheading:3264321-Immunologic Deficiency Syndromes,
pubmed-meshheading:3264321-Liver,
pubmed-meshheading:3264321-Mice,
pubmed-meshheading:3264321-Mice, Inbred Strains,
pubmed-meshheading:3264321-Stem Cells,
pubmed-meshheading:3264321-X Chromosome
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Strain variation in the frequency of Abelson murine leukemia virus-transformed fetal liver pre-B cells bearing complete immunoglobulin heavy chain rearrangements.
|
|
pubmed:affiliation |
Immunology Program, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
