Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-1-17
pubmed:abstractText
In patients with rheumatoid arthritis (RA), circulating CD5+ B lymphocytes, but not CD5- B lymphocytes, are increased in number and size, exist in an activated state, spontaneously proliferate, and secrete Ig that binds to the Fc fragment of IgG. By constructing continuous mAb-secreting cell lines from CD5+ B lymphocytes, the properties and dissociation constants (Kd) of these antibodies were determined. Two types of rheumatoid factors (RFs) with discrete reactivities were produced. The first type is polyreactive and binds with relatively low affinity (Kd, 10(-5) mol/liter) to the Fc fragment of IgG. These antibodies are similar to those produced by CD5+ B cells from healthy subjects. The second type of RF is monoreactive and binds with higher affinity (Kd, 10(-7) mol/liter) to the Fc fragment of IgG. These latter autoantibodies are produced by CD5+ B cells of RA patients, but not healthy subjects. Long-term longitudinal studies are needed to determine the role of these two types of RFs in the pathogenesis of RA.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-13596783, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-2422209, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-2439101, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-2836625, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3020687, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3023521, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3073178, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3112220, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3259609, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3351435, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3480535, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3487614, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3495631, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3498121, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3500961, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3552341, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3804365, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3890479, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3899124, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-3981007, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-6217058, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-639341, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-6601551, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-6609363, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-6977012, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264319-7015346
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1979-92
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.
pubmed:affiliation
Laboratory of Oral Medicine, National Institute of Dental Research, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article