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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-1-3
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pubmed:abstractText |
The plasma half-life of recombinant human interleukin-6 (rhIL-6) was determined in rats by measuring the disappearance of the biological activity as well as of the radioactivity of 125I-rhIL-6 from the circulation. The kinetics of clearance were biphasic. It consisted of a rapid initial disappearance corresponding to a half-life of 3 min, and of a second slow one corresponding to a half-life of about 55 min. By cellulose-acetate electrophoresis it was shown that rhIL-6 binds to a plasma protein resulting in a complex migrating in the beta-gamma region; 20 min after intravenous injection, about 80% of the 125I-rhIL-6 that had disappeared from the circulation was found in the liver. 125I-rhIL-6 was exclusively localized on the surface of parenchymal cells suggesting the existence of an interleukin-6 receptor on the hepatocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
357-61
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:3263918-Animals,
pubmed-meshheading:3263918-Autoradiography,
pubmed-meshheading:3263918-Blood Proteins,
pubmed-meshheading:3263918-Electrophoresis, Cellulose Acetate,
pubmed-meshheading:3263918-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3263918-Half-Life,
pubmed-meshheading:3263918-Interleukin-6,
pubmed-meshheading:3263918-Interleukins,
pubmed-meshheading:3263918-Iodine Radioisotopes,
pubmed-meshheading:3263918-Kinetics,
pubmed-meshheading:3263918-Liver,
pubmed-meshheading:3263918-Male,
pubmed-meshheading:3263918-Rats,
pubmed-meshheading:3263918-Rats, Inbred Strains,
pubmed-meshheading:3263918-Receptors, Immunologic,
pubmed-meshheading:3263918-Receptors, Interleukin-6,
pubmed-meshheading:3263918-Recombinant Proteins,
pubmed-meshheading:3263918-Tissue Distribution
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pubmed:year |
1988
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pubmed:articleTitle |
Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat.
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pubmed:affiliation |
Biochemisches Institut, Universität Freiburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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