| pubmed-article:3263568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0017636 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:3263568 | lifeskim:mentions | umls-concept:C0205254 | lld:lifeskim |
| pubmed-article:3263568 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3263568 | pubmed:dateCreated | 1988-12-21 | lld:pubmed |
| pubmed-article:3263568 | pubmed:abstractText | The gene encoding the receptor for epidermal growth factor was amplified two- to fivefold in the human glioblastoma cell line SF268. The amplified gene gave rise to abundant quantities of receptor that bound EGF with a high affinity (Kd, 0.35 nM). The binding of ligand failed to elicit cellular DNA synthesis, however, and the receptor was enzymatically inactive. We presume that the amplified receptor gene carries a mutation(s) that affects several aspects of the receptor's function. Characterization of the mutation(s) may illuminate how structure dictates function in the receptor protein. | lld:pubmed |
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| pubmed-article:3263568 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3263568 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3263568 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3263568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3263568 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3263568 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3263568 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3263568 | pubmed:author | pubmed-author:BishopJ MJM | lld:pubmed |
| pubmed-article:3263568 | pubmed:author | pubmed-author:WellsAA | lld:pubmed |
| pubmed-article:3263568 | pubmed:author | pubmed-author:HelmesteDD | lld:pubmed |
| pubmed-article:3263568 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3263568 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:3263568 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3263568 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3263568 | pubmed:pagination | 4561-5 | lld:pubmed |
| pubmed-article:3263568 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:3263568 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3263568 | pubmed:articleTitle | Amplified gene for the epidermal growth factor receptor in a human glioblastoma cell line encodes an enzymatically inactive protein. | lld:pubmed |
| pubmed-article:3263568 | pubmed:affiliation | G. W. Hooper Research Foundation, University of California, San Francisco 94143. | lld:pubmed |
| pubmed-article:3263568 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3263568 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3263568 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3263568 | lld:pubmed |
