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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1988-12-21
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pubmed:abstractText |
The gene encoding the receptor for epidermal growth factor was amplified two- to fivefold in the human glioblastoma cell line SF268. The amplified gene gave rise to abundant quantities of receptor that bound EGF with a high affinity (Kd, 0.35 nM). The binding of ligand failed to elicit cellular DNA synthesis, however, and the receptor was enzymatically inactive. We presume that the amplified receptor gene carries a mutation(s) that affects several aspects of the receptor's function. Characterization of the mutation(s) may illuminate how structure dictates function in the receptor protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2857420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2981413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2982800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2997213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2998356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2998607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-2998610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-3001490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-3004701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-3006920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-3019225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-3533968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-3535739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6090945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6092336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6253989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6277923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6318976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6327062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6328312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6329746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263568-6330080
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4561-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3263568-Cell Cycle,
pubmed-meshheading:3263568-DNA,
pubmed-meshheading:3263568-Epidermal Growth Factor,
pubmed-meshheading:3263568-Gene Amplification,
pubmed-meshheading:3263568-Glioma,
pubmed-meshheading:3263568-Humans,
pubmed-meshheading:3263568-Mutation,
pubmed-meshheading:3263568-Protein-Tyrosine Kinases,
pubmed-meshheading:3263568-Receptor, Epidermal Growth Factor,
pubmed-meshheading:3263568-Structure-Activity Relationship,
pubmed-meshheading:3263568-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
Amplified gene for the epidermal growth factor receptor in a human glioblastoma cell line encodes an enzymatically inactive protein.
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pubmed:affiliation |
G. W. Hooper Research Foundation, University of California, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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