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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1988-12-8
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pubmed:abstractText |
In the process of evaluating murine hybridomas for an antibody to the beta-subunit of the IL-2R (p70) we identified an antibody that immunoprecipitated a 55- to 57-kDa complex from cross-linked lysates. We demonstrate that this complex is composed of IL-2 (15.5 kDa) cross-linked to the H chain of HLA class I (40 to 42 kDa), suggesting a molecular interaction between HLA class I molecules and IL-2R. Although the exact role of this association remains to be determined, the specific cross-linking of IL-2 to HLA class I Ag is intriguing in view of published claims for a role of HLA class I in OKT3-induced lymphocyte proliferation and in NK cell lytic activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3512-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3263428-Animals,
pubmed-meshheading:3263428-Antibodies, Monoclonal,
pubmed-meshheading:3263428-Cell Line,
pubmed-meshheading:3263428-Cross-Linking Reagents,
pubmed-meshheading:3263428-Female,
pubmed-meshheading:3263428-HLA Antigens,
pubmed-meshheading:3263428-Histocompatibility Antigens Class I,
pubmed-meshheading:3263428-Humans,
pubmed-meshheading:3263428-Hybridomas,
pubmed-meshheading:3263428-Mice,
pubmed-meshheading:3263428-Mice, Inbred BALB C,
pubmed-meshheading:3263428-Precipitin Tests,
pubmed-meshheading:3263428-Receptors, Interleukin-2,
pubmed-meshheading:3263428-T-Lymphocytes
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pubmed:year |
1988
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pubmed:articleTitle |
Possible association between IL-2 receptors and class I HLA molecules on T cells.
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pubmed:affiliation |
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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