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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-12-14
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pubmed:abstractText |
Acylation of cellular proteins with the fatty acids myristate or palmitate represents an important mechanism for the co- or posttranslational modification of proteins. Lipid A, the biologically active component of bacterial endotoxin, exerts a number of biochemical effects on responsive cell types. Evidence is presented that lipid A stimulates the synthesis and subsequent myristyl acylation of intracellular monocyte and glomerular mesangial cell proteins. Two of the myristylated monocyte proteins were identified by specific immunoprecipitation as the 33-kD IL 1 alpha and beta precursors; a similar myristylated protein was found in mesangial cells. The 17-kD secretory form of monocyte IL 1 beta did not contain covalently linked myristate. Myristyl acylation of the IL 1 precursor proteins may facilitate the processing or membrane localization of these proteins, which lack characteristic hydrophobic signal sequences. The acylated 33-kD IL 1 alpha may remain preferentially associated with the membrane in an active form, whereas limited proteolysis may convert the biologically inactive IL 1 beta precursor into the extracellular, nonacylated, active 17-kD protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-236308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-2578046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-2950091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-2989698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3035380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3082977,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3106975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3108379,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3258335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3260603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3279153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3294853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3461461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3484502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3486219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3489936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3492551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3494069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3495584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3495585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3495602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-3573147,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-6595656,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3263392-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1479-88
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3263392-Acylation,
pubmed-meshheading:3263392-Animals,
pubmed-meshheading:3263392-Glomerular Mesangium,
pubmed-meshheading:3263392-Hydrogen-Ion Concentration,
pubmed-meshheading:3263392-Interleukin-1,
pubmed-meshheading:3263392-Lipid A,
pubmed-meshheading:3263392-Male,
pubmed-meshheading:3263392-Methionine,
pubmed-meshheading:3263392-Molecular Weight,
pubmed-meshheading:3263392-Monocytes,
pubmed-meshheading:3263392-Myristic Acid,
pubmed-meshheading:3263392-Myristic Acids,
pubmed-meshheading:3263392-Protein Precursors,
pubmed-meshheading:3263392-Rats,
pubmed-meshheading:3263392-Rats, Inbred Strains
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pubmed:year |
1988
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pubmed:articleTitle |
Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.
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pubmed:affiliation |
Medical Service, Seattle Veterans Administration Medical Center-University of Washington 98108.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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