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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1988-10-24
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pubmed:abstractText |
Nine healthy subjects, 19 patients with multiple myeloma (MM) and 21 patients with chronic uremia were given cefodizime (2 g i.v.) at 2 different timepoints either in the morning or in the evening for 5 to 7 consecutive days. The following immunological parameters were comparatively evaluated before and after cefodizime administration: rosette-forming cells (RFC%), T lymphocyte subpopulations, monocyte chemotaxis index (MCI) and granulocyte chemotaxis index (GCI). Independently of the time of drug administration, a circadian rhythm was clearly detected (90% CI) as regards RFC%, CD3, CD4, CD8, CD4/CD8 before and RFC%, CD3, CD4, CD8, GCI after therapy. In addition, in patients treated at 0800 cefodizime increased the MESOR of the MCI and, to a lesser extent, of the GCI. The chronoimmunomodulatory effects of cefodizime in patients with MM and chronic uremia are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0390-0037
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-85
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3262046-Adjuvants, Immunologic,
pubmed-meshheading:3262046-Adult,
pubmed-meshheading:3262046-Aged,
pubmed-meshheading:3262046-Cefotaxime,
pubmed-meshheading:3262046-Chemotaxis, Leukocyte,
pubmed-meshheading:3262046-Circadian Rhythm,
pubmed-meshheading:3262046-Female,
pubmed-meshheading:3262046-Humans,
pubmed-meshheading:3262046-Kidney Failure, Chronic,
pubmed-meshheading:3262046-Leukocytes,
pubmed-meshheading:3262046-Male,
pubmed-meshheading:3262046-Middle Aged,
pubmed-meshheading:3262046-Multiple Myeloma,
pubmed-meshheading:3262046-Reference Values,
pubmed-meshheading:3262046-Rosette Formation,
pubmed-meshheading:3262046-T-Lymphocytes,
pubmed-meshheading:3262046-Uremia
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pubmed:articleTitle |
Toward a chronoimmunomodulation by cefodizime in multiple myeloma and chronic uremia.
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pubmed:affiliation |
Cattedra di Cronobiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Milano, Italy.
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pubmed:publicationType |
Journal Article
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