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rdf:type |
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lifeskim:mentions |
umls-concept:C0021027,
umls-concept:C0024299,
umls-concept:C0025936,
umls-concept:C0026336,
umls-concept:C0079068,
umls-concept:C0086222,
umls-concept:C0086418,
umls-concept:C0312738,
umls-concept:C1704689,
umls-concept:C1705733,
umls-concept:C1879547
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pubmed:issue |
16
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pubmed:dateCreated |
1988-10-5
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pubmed:abstractText |
Transgenic mice carrying a fusion gene in which the mouse immunoglobulin enhancer has been inserted into an otherwise normal human c-myc gene develop a narrow spectrum of pre-B-cell lymphomas. Tumor occurrence is correlated with expression of the transgene in organs in which large numbers of pre-B cells predominate. These tumors, which arise stochastically, are virtually all lymphoblastic lymphomas of the pre-B-cell type. Evidently the isolated enhancer targets oncogene expression and tumorigenesis to the early B-cell population in preference to more mature B-cell populations. The transgene also confers enhanced in vitro growth properties on nontransformed pre-B cells as observed in bone marrow cultures derived from transgenic animals. These cultured cells represent a population in which the activating function of c-myc can be uncoupled from secondary oncogenic events occurring in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-111146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-3011271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-3037318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-3093082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-3906410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6273911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6304883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6356357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6409418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6414718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6488314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6605691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6771020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261863-6980414
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6047-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3261863-Animals,
pubmed-meshheading:3261863-B-Lymphocytes,
pubmed-meshheading:3261863-Cells, Cultured,
pubmed-meshheading:3261863-Disease Models, Animal,
pubmed-meshheading:3261863-Enhancer Elements, Genetic,
pubmed-meshheading:3261863-Genes, Immunoglobulin,
pubmed-meshheading:3261863-Humans,
pubmed-meshheading:3261863-Lymphoma,
pubmed-meshheading:3261863-Mice,
pubmed-meshheading:3261863-Mice, Transgenic,
pubmed-meshheading:3261863-Phenotype,
pubmed-meshheading:3261863-Precancerous Conditions,
pubmed-meshheading:3261863-Proto-Oncogenes,
pubmed-meshheading:3261863-Recombination, Genetic
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pubmed:year |
1988
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pubmed:articleTitle |
Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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