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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1988-8-19
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pubmed:abstractText |
Using synthetic peptides, we characterized the B-lymphocyte (antibody) and T-lymphocyte (proliferation) responses to an immunodominant epitope of human immunodeficiency virus type 1 (HIV-1) located near the amino-terminal end of the transmembrane glycoprotein (env amino acids 598 to 609). Both immunoglobulin M (IgM) and IgG antibodies against this epitope appeared early after primary infection with HIV-1. In an animal model, the IgG response to a synthetic peptide derived from this sequence was T-helper-cell dependent, whereas the IgM response was T-cell independent. In addition, antibody generated by immunization with this peptide had HIV-1-neutralizing activity. Greater than 99% (201 of 203) of patients infected with HIV-1 generated antibody to this peptide in vivo; however, only 24% (7 of 29) had T cells that proliferated in response to this peptide in vitro. These observations suggest that different HIV-1 gp41 epitopes elicit B-cell and T-cell immune responses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2413136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2424612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2426711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2431324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2431482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2432599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2433466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2437327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2438302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2438696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2439614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2439707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2440037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2441877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2443856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2444892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2875298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2877159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2879968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2888192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2944982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2981635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2989707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-2990634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3013415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3014529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3014647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3018753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3031510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3033328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3093891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3466790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3474300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3475581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3476491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3495568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3496541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3497202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3553344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-3629244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-4307033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-6085753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3260630-84683
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2531-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3260630-Animals,
pubmed-meshheading:3260630-Antibody Formation,
pubmed-meshheading:3260630-Antigens, Viral,
pubmed-meshheading:3260630-B-Lymphocytes,
pubmed-meshheading:3260630-HIV,
pubmed-meshheading:3260630-HIV Seropositivity,
pubmed-meshheading:3260630-Humans,
pubmed-meshheading:3260630-Lymphocyte Activation,
pubmed-meshheading:3260630-Mice,
pubmed-meshheading:3260630-Neutralization Tests,
pubmed-meshheading:3260630-Peptide Fragments,
pubmed-meshheading:3260630-T-Lymphocytes,
pubmed-meshheading:3260630-Time Factors,
pubmed-meshheading:3260630-Viral Envelope Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus.
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pubmed:affiliation |
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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