Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-8-4
|
| pubmed:abstractText |
Myocardial injury after aorto-coronary bypass surgery was estimated in 72 patients from total release into plasma of cardiac creatine kinase (CK-MB) and alpha-hydroxybutyrate dehydrogenase (HBD). Activities of CK-MB were determined both by immuno-inhibition of CK-M units and by ion-exchange chromatography. After correction for per-operative hemolysis, the estimates based on HBD were in agreement with the estimates based on CK-MB as determined by the ion-exchange method. Both enzymes indicated a mean loss of only about 2 gram-equivalents of myocardium. Such minimal injury was also found in metabolic and ultrastructural studies of myocardial biopsies in the same patients, as reported earlier. However, approximately two-fold larger estimates of injury were obtained from plasma CK-MB activities determined by immuno-inhibition. This apparent extra release of CK-MB runs parallel with massive release of CK-activity from skeletal muscle damaged by surgery. Taking also into account the various calculation methods used by different authors, overestimates as large as 10-20 gram-equivalents of lost myocardium after uncomplicated bypass surgery, as published in the literature, can be explained.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0009-8981
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
173
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
243-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
Minimal myocardial injury after uncomplicated coronary bypass surgery. Various sources of overestimation.
|
| pubmed:affiliation |
Department of Biophysics, University of Limburg, Maastricht, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|