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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1988-6-28
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pubmed:abstractText |
The nigrostriatal dopaminergic neurotoxicity of MPTP was prevented in mice in a dose-dependent manner by the monoamine oxidase-B (MAO-B) inhibitor deprenyl. This finding, combined with other observations, points out the important role of MAO-B in the bioactivation of MPTP. In the present study, some comparisons between MPTP and several of its structural analogs will be presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0300-483X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-501
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3259742-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:3259742-1-Methyl-4-phenylpyridinium,
pubmed-meshheading:3259742-Animals,
pubmed-meshheading:3259742-Dose-Response Relationship, Drug,
pubmed-meshheading:3259742-Male,
pubmed-meshheading:3259742-Mice,
pubmed-meshheading:3259742-Monoamine Oxidase Inhibitors,
pubmed-meshheading:3259742-Pyridines,
pubmed-meshheading:3259742-Pyridinium Compounds,
pubmed-meshheading:3259742-Receptors, Dopamine,
pubmed-meshheading:3259742-Structure-Activity Relationship
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|
pubmed:year |
1988
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|
pubmed:articleTitle |
Studies with the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and several of its analogs.
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pubmed:affiliation |
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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