Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1988-7-1
|
pubmed:abstractText |
The purpose of the present work was to study the effect of vitamin D and its metabolites in correcting hypovitaminosis D in the elderly. Thirty elderly people (mean age 78.4 years) participated in this study. They all had low serum levels of 25-hydroxyvitamin D (25-OH-D), of 24,25-dihydroxyvitamin D [24,25(OH)2D] and of 1,25-dihydroxyvitamin D [1,25(OH)2D]. These low levels did not increase in nine subjects after oral administration of vitamin D2 (3,000 IU/day for 12 weeks). However, administration of 1 alpha-hydroxyvitamin D3 (1 alpha-OH-D3) to 12 other subjects (0.5 micrograms/day for 8 weeks) led to a significant increase in the serum levels of 1,25(OH)2D. The other vitamin D metabolite levels remained unchanged. A significant increase in the levels of all three main vitamin D metabolites was obtained following administration of 25-hydroxyvitamin D3 (25-OH-D3) to a third group of nine subjects (25 micrograms/day for 1 week). These results suggest that vitamin D nutrition in elderly people insufficently exposed to the sun could be maintained by regular administration of 25-OH-D, whereas the administration of native vitamin D (ergocalciferol) in the doses used was inadequate for vitamin D nutrition.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/24,25-Dihydroxyvitamin D 3,
http://linkedlifedata.com/resource/pubmed/chemical/Calcifediol,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroxycholecalciferols,
http://linkedlifedata.com/resource/pubmed/chemical/Ergocalciferols,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxycholecalciferols
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0021-2180
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
160-3
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3259568-24,25-Dihydroxyvitamin D 3,
pubmed-meshheading:3259568-Aged,
pubmed-meshheading:3259568-Aged, 80 and over,
pubmed-meshheading:3259568-Calcifediol,
pubmed-meshheading:3259568-Calcitriol,
pubmed-meshheading:3259568-Dihydroxycholecalciferols,
pubmed-meshheading:3259568-Ergocalciferols,
pubmed-meshheading:3259568-Female,
pubmed-meshheading:3259568-Humans,
pubmed-meshheading:3259568-Hydroxycholecalciferols,
pubmed-meshheading:3259568-Male,
pubmed-meshheading:3259568-Vitamin D Deficiency
|
pubmed:year |
1988
|
pubmed:articleTitle |
Vitamin D-deficiency in the elderly: treatment with ergocalciferol and hydroxylated analogues of vitamin D3.
|
pubmed:affiliation |
Department of Clinical Biochemistry, Soroka Medical Center, Beer Sheva, Israel.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|