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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-6-16
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pubmed:abstractText |
An inhibitor-proteinase complex consisting of human alpha 1-PI and human leukocyte elastase is chemotactic for human neutrophils. The chemotactic activity is optimal at 1 nM and is associated only with the alpha 1-PI portion of the complex. Neither HLE in the complex, free HLE, nor native alpha 1-PI possesses chemotactic activity for human neutrophils. alpha 1-PI in complex is hydrolyzed at the Met-358-Ser-359 bond. The chemotactic activity is associated with the Mr 4,200 fragment of alpha 1-PI that has Ser-359 as its NH2 terminus. The region of the HLE-alpha 1-PI complex that stimulates chemotaxis appears to be the same as that of the Mr 4,200 fragment generated by hydrolysis of the Pro-357-Met-358 bond during proteolytic inactivation of alpha 1-PI. The data suggest the presence of a neutrophil surface receptor bound by alpha 1-PI after the formation of a complex with HLE or after proteolytic degradation. This receptor may play a role in clearance of these modified alpha 1-PI molecules.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-3494748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-3871944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-59654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6175245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6193754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6332197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6602020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6915940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6945600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6969773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-6989830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-7076844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-88449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3259253-88450
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1608-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3259253-Blood Proteins,
pubmed-meshheading:3259253-Chemotactic Factors,
pubmed-meshheading:3259253-Humans,
pubmed-meshheading:3259253-Leukocyte Elastase,
pubmed-meshheading:3259253-Neutrophils,
pubmed-meshheading:3259253-Pancreatic Elastase,
pubmed-meshheading:3259253-Peptide Fragments,
pubmed-meshheading:3259253-Receptors, Formyl Peptide,
pubmed-meshheading:3259253-Receptors, Immunologic,
pubmed-meshheading:3259253-alpha 1-Antitrypsin
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pubmed:year |
1988
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pubmed:articleTitle |
The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant.
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pubmed:affiliation |
Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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