Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
|
pubmed:dateCreated |
1988-6-3
|
pubmed:abstractText |
The investigational drug flavone-8-acetic acid (FAA) potently augments NK activity in the spleen, liver, lungs, and peritoneum in a dose-dependent manner after i.v. or i.p. administration. Augmented NK activity peaks by 24 h after FAA injection and returns to normal after 6 days. Combined treatment of established murine renal cancer with FAA and rIL-2 results in up to 80% long term survival whereas FAA or rIL-2 alone were unable to induce any long term survivors. The optimal dose of rIL-2 required for use with FAA was in the range of 10,000 to 30,000 U/day. Further studies demonstrated that the regimen of FAA plus rIL-2 administration that was effective in treating established murine renal cancer also induced a more potent augmentation of NK activity than did either FAA or rIL-2 alone. Subsequent studies revealed that the therapeutic effectiveness of FAA plus rIL-2 was significantly reduced when tumor-bearing mice were treated with anti-asialo GM1 serum. These results are consistent with a role for augmented NK activity in the therapeutic effects of FAA plus rIL-2 murine renal cancer. In addition, these studies demonstrate that FAA and rIL-2 is a useful approach for cancer treatment in that subtoxic doses of rIL-2 can be used and significant anti-tumor efficacy occurs even without accompanying adoptive immunotherapy.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/G(M1) Ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosphingolipids,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/asialo GM1 ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/flavone acetic acid
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0022-1767
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
140
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3261-5
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:3258894-Animals,
pubmed-meshheading:3258894-Antineoplastic Agents,
pubmed-meshheading:3258894-Cytotoxicity, Immunologic,
pubmed-meshheading:3258894-Drug Synergism,
pubmed-meshheading:3258894-Flavonoids,
pubmed-meshheading:3258894-G(M1) Ganglioside,
pubmed-meshheading:3258894-Glycosphingolipids,
pubmed-meshheading:3258894-Immunity, Innate,
pubmed-meshheading:3258894-Immunotherapy,
pubmed-meshheading:3258894-Interleukin-2,
pubmed-meshheading:3258894-Kidney Neoplasms,
pubmed-meshheading:3258894-Killer Cells, Natural,
pubmed-meshheading:3258894-Mice
|
pubmed:year |
1988
|
pubmed:articleTitle |
Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer.
|
pubmed:affiliation |
Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research Facility.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|