Linked Life Data

3258469

Source:http://linkedlifedata.com/resource/pubmed/id/3258469

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-5-12
pubmed:abstractText
Young and adult, intact and ovariectomized female rats were used to study the effects of increasing age and estrogen loss on the conversion of 25-hydroxycholecalciferol [25(OH)D] to 1,25-dihydroxycholecalciferol [1,25(OH)2D] and 24,25-dihydroxycholecalciferol [24,25(OH)2D]. The recovery level of radioactivity in plasma as 1,25(OH)2D after [3H]25(OH)D administration was lower in older animals; ovariectomy reduced [3H]1,25(OH)2D recovery in both young and adult animals. 1,25(OH)2D synthesis by kidney slices was reduced in all adult animals and in ovariectomized young animals. Calcium absorption was also lower in adult animals and in young ovariectomized animals then in controls. Beta-estradiol administration increased recovery of [3H]1,25(OH)2D but not [3H]24,25(OH)2D, which is parallel to the general lack of effect of ovariectomy on 24,25(OH)2D production. Parathyroidectomy eliminated the estrogen effect on 1,25(OH)2D production. Thus, estrogen loss and advancing age reduced 1,25(OH)2D production and Ca absorption independently, the estrogen effect being mediated via the parathyroid gland.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
694-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of age and estrogen on renal vitamin D metabolism in the female rat.
pubmed:affiliation
Department of Community Health, Tufts University School of Medicine, Boston, MA 02111.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.