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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-5-2
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pubmed:abstractText |
Serum antibodies in some patients with systemic lupus erythematosus (SLE) were found to have specificity to idiotypes (Id) of 0-81 (human monoclonal anti-single-stranded DNA (ssDNA) antibody) but not to Id of NE-1 (human monoclonal anti-double-stranded DNA (dsDNA) antibody) or pooled human IgM. The interaction of the antibodies and 0-81 was blocked by the co-existence of free ssDNA. Some of SLE sera also showed preferential binding to Id determinants of NE-1, which included the antigen-binding sites of the dsDNA antibody. Some other SLE sera reacted with both Id of 0-81 and NE-13. Thus, there was heterogeneous population among human anti-Id autoantibodies to anti-DNA antibodies. The anti-Id activity was commonly detected in inactive SLE sera, and less frequently in normal controls, suggesting some regulatory role for anti-Id antibodies in the production of autoantibodies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-2413066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-2427543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-2937806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-3027184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-3484765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-3487551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-3876101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-4102680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6147499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6402708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6431009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6606665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6697565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6971876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3258206-6983943
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3258206-Animals,
pubmed-meshheading:3258206-Antibodies, Antinuclear,
pubmed-meshheading:3258206-Antibodies, Monoclonal,
pubmed-meshheading:3258206-Autoantibodies,
pubmed-meshheading:3258206-Binding, Competitive,
pubmed-meshheading:3258206-DNA,
pubmed-meshheading:3258206-Humans,
pubmed-meshheading:3258206-Immunoglobulin Idiotypes,
pubmed-meshheading:3258206-Lupus Erythematosus, Systemic,
pubmed-meshheading:3258206-Mice,
pubmed-meshheading:3258206-Species Specificity
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pubmed:year |
1988
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pubmed:articleTitle |
Heterogeneity of anti-idiotypic antibodies to anti-DNA antibodies in humans.
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pubmed:affiliation |
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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